This white paper provides an overview and recommendations for how to get the most from the IBM Lotus Notes 8.5.2 client on the Citrix XenApp 5.0 server. Specifically, it shows that by tuning the environment, you can realize significant improvements when running the Notes client on XenApp. This is true for both the standard and the basic configurations of Lotus Notes. Moreover, the new support for Microsoft Windows 2008 SP2 by Notes 8.5.2, together with memory improvements, means increased scalability to even higher numbers than before at a much reduced cost. We also present the testing environment, tuning parameters, and the workflows that were executed to gather the scalability data on Notes 8.5.2.